Artem Efremov Lab

1. M.I. Molodtsov, E.L. Grishchuk, A.K. Efremov, J.R. McIntosh, F.I. Ataullakhanov. 2005. Force production by depolymerizing microtubules: a theoretical study. Proc. Natl. Acad. Sci. USA, 102:4353-8.

[F1000 recommendation]

Web-link: http://www.pnas.org/content/102/12/4353


2. Artem Efremov, Ekaterina L. Grishchuk, J. Richard McIntosh,Fazly I. Ataullakhanov. 2007. In search of an optimal ring to couple microtubule depolymerization to processive chromosome motions. Proc. Natl. Acad. Sci. USA, 104:19017-22.

Web-link: http://www.pnas.org/content/104/48/19017


3. E. L. Grishchuk, I. S. Spiridonov, V. A. Volkov, A. Efremov, S. Westermann, D. Drubin, G. Barnes, F. I. Ataullakhanov, and J. R. McIntosh. 2008. Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanism. Proc. Natl. Acad. Sci. USA, 105:6918-23.

[F1000 recommendation]

Web-link: http://www.pnas.org/content/105/19/6918


4. J.R. McIntosh, E.L. Grishchuk, M. Morphew, A.K. Efremov, K. Zhudenkov, V. Volkov, I. Cheeseman, A. Desai, D.N. Mastronarde, F.I. Ataullakhanov. 2008. Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell, 135:322-33.

[F1000 recommendation]

Web-link: https://www.cell.com/cell/fulltext/S0092-8674(08)01119-7


5. Ekaterina L. Grishchuk, Artem K. Efremov, Vladimir A. Volkov, Ilia S. Spiridonov, Nikita Gudimchuk, Stefan Westermann, David Drubin, Geojana Barnes, J. Richard McIntosh, and Fazly I. Ataullakhanov. 2008. The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion. Proc. Natl. Acad. Sci. USA, 105:15423-8.

Web-link: http://www.pnas.org/content/105/40/15423


6. Artem Efremov*, Zhisong Wang*. 2011. Maximum directionality and systematic classification of molecular motors. Phys. Chem. Chem. Phys., 13:5159-5170.

Web-link: http://pubs.rsc.org/en/content/articlelanding/2011/cp/c0cp02519d/#!divAbstract


7. Artem Efremov*, Zhisong Wang*. 2011. Universal optimal working cycles of molecular motors. Phys. Chem. Chem. Phys., 13:6223-6233.

Web-link: http://pubs.rsc.org/en/content/articlelanding/2011/cp/c0cp02118k/#!divAbstract


8. Artem Efremov*, Jianshu Cao*. 2011. Bistability of cell adhesion in shear flow. Biophys. J., 101:1032-1040.

Web-link: https://www.cell.com/biophysj/fulltext/S0006-3495(11)00884-8


9. Hailong Lu^#, Artem K. Efremov^#, Carol S. Bookwalter, Elena B. Krementsova, Jonathan W. Driver, Kathleen M. Trybus, and Michael R. Diehl. 2012. Collective dynamics of elastically-coupled myosin V motors. J. Biol. Chem., 287:27753-61.

Web-link: http://www.jbc.org/content/287/33/27753


10. Karthik Uppulury, Artem Efremov, Jonathan Driver, Kenneth, Jamison, Michael R. Diehl, and Anatoly B. Kolomeisky. 2012. How the interplay between mechanical and non-mechanical interactions affects multiple kinesin dynamics. J. Phys. Chem. B, 116:8846-55.

Web-link: https://pubs.acs.org/doi/abs/10.1021/jp304018b


11. Juan Cheng, Sarangapani Sreelatha, Ruizheng Hou, Artem Efremov, Ruchuan Liu, Johan R.C. van der Maarel, Zhisong Wang. 2012. Bipedal nanowalker by pure physical mechanisms. Phys. Rev. Lett., 109:238104.

[Highlighted by American Physical Society]

Web-link: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.109.238104


12. Karthik Uppulury, Artem K. Efremov, Jonathan W. Driver, D. Kenneth Jamison, Michael R. Diehl,and Anatoly B. Kolomeisky. 2013. Analysis of cooperative behavior in multiple kinesins motor protein transport by varying structural and chemical properties. Cell Mol. Bioeng., 6:38-47.

Web-link: https://link.springer.com/article/10.1007%2Fs12195-012-0260-9


13. Xiaofeng Xu, Artem K. Efremov, Ang Li, Lipeng Lai, Ming Dao, Chwee Teck Lim, Jianshu Cao. 2013. Probing the cytoadherence of malaria infected red blood cells under flow. PLoS One, 8:e64763.

Web-link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064763


14. Zhisong Wang, Ruizheng Hou, Artem Efremov. 2013. Directional fidelity of nanoscale motors and particles is limited by the 2^nd law of thermodynamics - via a universal equality. J. Chem. Phys., 139:035105.

Web-link: https://aip.scitation.org/doi/abs/10.1063/1.4813626?journalCode=jcp


15. Artem K. Efremov^#, Anand Radhakrishan^#, David S. Tsao, Carol S. Brookwalter, Kathleen M. Trybus, and Michael R. Diehl. 2014. Delineating cooperative responses of processive motors in living cells. Proc. Natl. Acad. Sci. USA, 111:E334-43.

[Highlighted by ScienceDaily, Phys.org and several other news outlets]

Web-link: http://www.pnas.org/content/111/3/E334


16. Xu Yue, Chen Hu, Qu Yu-Jie, Artem K. Efremov, Li Ming, Ouyang Zhong-Can, Liu Dong-Sheng, Yan Jie. 2014. Mechano-chemical selections of two competitive unfolding pathways of a single DNA i-motif. Chin. Phys. B, 23:068702.

Web-link: http://iopscience.iop.org/article/10.1088/1674-1056/23/6/068702/meta


17. Huijuan You, Xiangjun Zeng, Yue Xu, Ci Ji Lim, Artem K. Efremov, Anh Tuan Phan, Jie Yan. 2014. Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. Nucleic Acids Res., 42:8789-95.

Web-link: https://academic.oup.com/nar/article/42/13/8789/1298035


18. Mingxi Yao, Wu Qiu, Ruchuan Liu, Artem K. Efremov, Peiwen Cong, Rima Seddiki, Manon Payre, Lim Chwee Teck, Benoit Ladoux, Rene-Marc Mege, Jie Yan. 2014. Force-dependent conformational switch of alpha-catenin controls vinculin binding. Nat. Commun., 5:4525.

Web-link: https://www.nature.com/articles/ncomms5525


19. Iong Ying Loh, Juan Cheng, Shern Ren Tee, Artem Efremov, Zhisong Wang. 2014. From bi-state molecular switches to self-directed track-walking nanomotors. ACS Nano, 8:10293-304.

Web-link: https://pubs.acs.org/doi/abs/10.1021/nn5034983


20. Artem K. Efremov, Yuanyuan Qu, Hugo Maruyama, Ci J. Lim, Kunio Takeyasu, Jie Yan. 2015. Transcriptional repressor TrmBL2 from Thermococcus kodakarensis forms filamentous nucleoprotein structures and competes with histones for DNA binding in a salt- and DNA supercoiling-dependent manner. J. Biol. Chem., 290:15770-84.

Web-link: http://www.jbc.org/content/290/25/15770


21. Shimin Le, Mingxi Yao, Jin Chen, Artem K. Efremov, Sara Azimi, Mark B. H. Breese, Jie Yan. 2015. Disturbance-free rapid solution exchange for magnetic tweezers single-molecule studies. Nucleic Acids Res., 43:e113.

Web-link: http://www.jbc.org/content/290/25/15770


22. Artem K. Efremov*, Ricksen S. Winardhi, Jie Yan*. 2016. Transfer-matrix calculation of DNA polymer micromechanics under tension and torque constraints. Phys. Rev. E, 94:032404.

[Editors' suggestion]

Web-link: https://journals.aps.org/pre/abstract/10.1103/PhysRevE.94.032404


23. Artem K. Efremov*, Ricksen S. Winardhi*, Jie Yan*. 2017. Theoretical methods for studying DNA structural transitions under applied mechanical constraints. Polymers, 9:74.

[Invited review]

Web-link: http://www.mdpi.com/2073-4360/9/2/74


24. Miao Yu, Xin Yuan, Chen Lu, Shimin Le, Ryo Kawamura, Artem K. Efremov, Zhihai Zhao, Michael Kozlov, Michael Sheetz, Alexander Bershadsky, Jie Yan. 2017. mDia1 senses both force and torque during F-actin filaments polymerization. Nat. Commun., 8:1650.

Web-link: https://www.nature.com/articles/s41467-017-01745-4


25. Artem K. Efremov*, Fazoil I. Ataullakhanov*. 2018. Atomic-scale insights into physical mechanisms driving enzymes "working cycles". Biophys. J., 114:2027-9.

[Invited commentary letter on "Motor-like properties of non-motor enzymes" paper by Slochower, D. R., and M. K. Gilson., Biophys. J., 2018]

Web-link: https://www.cell.com/biophysj/fulltext/S0006-3495(18)30444-2


26. Artem K. Efremov*, Jie Yan*. 2018. Transfer-matrix calculations of the effects of tension and torque constraints on DNA-protein interaction. Nucleic Acids Res., 46:6504-27.

Web-link: https://doi.org/10.1093/nar/gky478

Web-link, pre-print: https://arxiv.org/abs/1802.01437


27. Miao Yu, Shimin Le, Artem K. Efremov, Xiangjun Zeng, Alexander Bershadsky, Jie Yan. 2018. Effects of mechanical stimuli on profilin/formin-mediated actin polymerization. Nano Lett., 18:5239-47.

Web-link: https://pubs.acs.org/doi/10.1021/acs.nanolett.8b02211


28. N. O. Alieva^#, A. K. Efremov^#, S. Hu, D. Oh, M. Natarajan, H. T. Ong, A. Jegou, G. Romet-Lemonne, J. Groves, M. P. Sheetz, J. Yan and A. D. Bershadsky. 2017. Force dependence of filopodia adhesion: involvement of myosin II and formins. Nat. Commun.,10:3593

[F1000 recommendation]

Web-link, pre-print: https://www.biorxiv.org/content/early/2017/09/28/195420

Web-link: https://www.nature.com/articles/s41467-019-10964-w


29. Shiwen Guo, Artem K. Efremov and Jie Yan. 2019. Understanding the catch-bond kinetics of biomolecules on one-dimensional energy landscape. Chem. Comm., 2:30

Web-link: https://www.nature.com/articles/s42004-019-0131-6


30. Leo S. McCormack, Artem K. Efremov*, Jie Yan*. 2021. Effects of size, cooperativity and competitive binding on protein positioning on DNA. 2021. Biophys. J., 120:2040.

Web-link: https://www.sciencedirect.com/science/article/abs/pii/S0006349521002459


31. Artem K. Efremov*, Mingxi Yao, Michael P. Sheetz, Alexander Bershadsky, Boris Martinac and Jie Yan*. 2021. Application of pico-newton forces to individual filopodia reveals mechanosensory role of L-type Ca²⁺ channels.

Web-link: https://www.sciencedirect.com/science/article/abs/pii/S0142961222001168

Web-link, pre-print: https://www.biorxiv.org/content/10.1101/2020.10.21.346247v1


32. Yunxin Deng, Artem K. Efremov, Jie Yan. 2022. Modulating binding affinity, specificity, and configurations by multivalent interactions. 2022. Biophys. J., 121:1868.

Web-link: https://www.cell.com/biophysj/fulltext/S0006-3495(22)00316-2


33. Artem K. Efremov*, Ladislav Hovan, Jie Yan. Size of the cell nucleus and its effect on the chromatin structure in living cells. 2021. Biophys. J., 121:4189.

[Cover article]

Web-link: https://www.cell.com/biophysj/fulltext/S0006-3495(22)00769-X

Web-link, pre-print: https://www.biorxiv.org/content/10.1101/2021.07.27.453925v1

Highlighting article: https://www.biophysics.org/blog/nucleus-size-matters


34. Haifeng Xu, Song Wu, Yuan Liu, Xiaopu Wang, Artem K. Efremov, Lei Wang, John S. McCaskill, Mariana Medina-Sánchez, Oliver G. Schmidt. 3D nanofabricated soft microrobots with super-compliant picoforce springs as on-board sensors and actuators. 2024. Nat. Nanotechnol., 19:494.

[Highlighted by ScienceDaily, Phys.org and several other news outlets]

Web-link: https://www.nature.com/articles/s41565-023-01567-0


35. Yixuan Li, Hui Ting Ong, Hongyue Cui, Xu Gao, Jia Wen Nicole Lee, Yuqi Guo, Rong Li, Fabrizio A. Pennacchio, Paolo Maiuri, Artem K. Efremov, Andrew W. Holle. Confinement-sensitive volume regulation dynamics via high-speed nuclear morphological measurements. 2024. PNAS, 121:e2408595121.

Web-link: https://www.pnas.org/doi/abs/10.1073/pnas.2408595121


36. Ping Liu, Qiuyu Wang, Xin Dai, Lingxuan Pei, Junfan Wang, Weiyi Zhao, Heath E. Johnson, Mingxi Yao*, Artem K. Efremov*. Elastic properties of force-transmitting linkages determine multistable mechanosensitive behavior of cell adhesion. 2025. Nat. Phys., in publication.

Web-link, pre-print: https://www.biorxiv.org/content/10.1101/2023.09.04.554585v1

* - corresponding author
# - equal contribution
Total number of citations, Google Scholar
Web-link to ORCID: https://orcid.org/0000-0002-1603-610X
H-index, Google Scholar